The impacts on bone structures and metabolisms by high-fat diet caused osteoporosis in mice: a meta-analysis and systematic review

Abstract

ABSTRACTOsteoporosis (OP) is one of the epidemic diseases worldwide. Recently, a high-fat diet (HFD) makes the effects on skeletal microarchitecture still unclear. To explain the problem, we searched studies from PubMed, Embase, Web of Science, and Cochrane library to investigate the effect of HFD-induced obesity on bone structure and metabolism for mice from June 2010 to June 2020. Finally, eight publications were included. The results showed BV/TV was significantly decreased in HFD than control diet (CD) (SMD −4.24, 95% CI: −6.60, −1.87, p < .001), Tb.N (SMD −2.98, 95% CI: −4.89, −1.06, p = .002) and Tb.Th (SMD −1.26, 95% CI: −1.93, −0.59, p < .001) were significantly decreased. Tb.Sp (SMD 2.38, 95% CI:1.04, 3.72, p < .001) and SMI (SMD 3.86, 95% CI: 1.79, 5.93, p < .001) were significantly increased in HFD. In conclusion, HFD accelerated OP progression which reflected on LDL, leptin, osteocalcin (OCN) and osteoprotegerin (OPG).

Keywords

• Osteoporosis
• high-fat diet
• meta-analysis