Iridoid glycosides from the flower buds of Lonicera japonica and their nitric oxide production and α-glucosidase inhibitory activities

Zhi-Xiang Liu; Chun-Ting Liu; Qing-Bo Liu; Jie Ren; Ling-Zhi Li; Xiao-Xiao Huang; Zhen-Zhong Wang; Shao-Jiang Song

Journal of Functional Foods (Oct 2015)

Iridoid glycosides from the flower buds of Lonicera japonica and their nitric oxide production and α-glucosidase inhibitory activities

Zhi-Xiang Liu,
Chun-Ting Liu,
Qing-Bo Liu,
Jie Ren,
Ling-Zhi Li,
Xiao-Xiao Huang,
Zhen-Zhong Wang,
Shao-Jiang Song

Affiliations

Zhi-Xiang Liu: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Chun-Ting Liu: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Qing-Bo Liu: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Jie Ren: School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China
Ling-Zhi Li: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Xiao-Xiao Huang: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Zhen-Zhong Wang: Jiangsu Kanon Pharmaceutical Co., Ltd, Lianyungang 222001, China
Shao-Jiang Song: Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding author. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Tel.: +86 24 23986088; fax: +86 24 23986510..

Journal volume & issue: Vol. 18
pp. 512 – 519

Abstract

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The flower buds of Lonicera japonica are commonly used as popular healthy beverages that are also effective in the prevention and cure of a variety of chronic diseases, such as diabetes, and also as an anti-inflammatory treatment for thousands of years. In this study, three new iridoid glycosides along with twenty-five known analogues were isolated from the aqueous extract of L. japonica. Their structures were determined by extensive 1D NMR, 2D NMR and HR-ESIMS spectroscopic data analyses, and all the isolates were investigated with regard to lipopolysaccharide (LPS)-induced nitric oxide (NO) production and α-glucosidase inhibitory effects. Among these compounds, 12 and 13 exhibited strong NO inhibitory activities and no cytotoxic effects. Moreover, most compounds were potent α-glucosidase inhibitors compared with the positive control acarbose. These findings will enhance knowledge about the bioactive components of L. japonica and help promote its potential application in functional foods.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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