Optimization of the Ultrasonic Extraction Process of Acanthopanax senticosus Multiple Components Based on a Coupling Methodology of Analytic Hierarchy Process and Entropy Weight Method

Yamei LIN; Hongxin ZHI; Jixiang SUN; Boyu CHEN; Shengkai LIU; Zhiguo LIU

doi:10.13386/j.issn1002-0306.2022120137

Shipin gongye ke-ji (Oct 2023)

Optimization of the Ultrasonic Extraction Process of Acanthopanax senticosus Multiple Components Based on a Coupling Methodology of Analytic Hierarchy Process and Entropy Weight Method

Yamei LIN,
Hongxin ZHI,
Jixiang SUN,
Boyu CHEN,
Shengkai LIU,
Zhiguo LIU

Affiliations

Yamei LIN: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China
Hongxin ZHI: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China
Jixiang SUN: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China
Boyu CHEN: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China
Shengkai LIU: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China
Zhiguo LIU: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China

DOI: https://doi.org/10.13386/j.issn1002-0306.2022120137
Journal volume & issue: Vol. 44, no. 20
pp. 239 – 249

Abstract

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The multi-component ultrasonic extraction process of Acanthopanax senticosus was optimized via ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS/MS) quantitative method and the multi-index comprehensive evaluation method. An UPLC-MS/MS method for the simultaneous quantitative determination of multiple components (chlorogenic acid, syringin, eleutheroside E, isofraxidin, caffeic acid and sesamin) in rhizome of Acanthopanax senticosus was developed. Then, the analytic hierarchy process (AHP) and entropy weight method (EWM) were combined to establish a multi-index comprehensive evaluation method (AHP-EWM method）. Finally, the multi-component ultrasonic extraction process of Acanthopanax senticosus was optimized by single factor combined with response surface methodology (RSM) based on Box-Behnken design (BBD). The results revealed that the optimal process of ultrasonic extraction of multiple components of Acanthopanax senticosus obtained by RSM optimization was as follows: Ultrasonic power 780 W, ultrasonic time 17.5 min, ethanol volume fraction 57%, solid-liquid ratio 1:40 g:mL, raw material particle size 80 mesh. Therefore, the contents of chlorogenic acid, syringin, eleutheroside E, isofraxidin, caffeic acid and sesamin in rhizome of Acanthopanax senticosus were 2235.841±12.17，517.959±6.09，861.247±5.30，66.657±1.22，45.745±0.77，99.355±0.69 μg/g, respectively. The comprehensive score based on the AHP-EWM method was 95.45±0.39, which was close to the predicted theoretical value. The effective development of quantitative analysis method and efficient extraction technology of Acanthopanax senticosus have laid a foundation for its resource utilization and pharmacodynamic basic research.

Published in Shipin gongye ke-ji

ISSN: 1002-0306 (Print)
Publisher: The editorial department of Science and Technology of Food Industry
Country of publisher: China
LCC subjects: Technology: Chemical technology: Food processing and manufacture
Website: http://www.spgykj.com/indexen.htm

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