Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice

Bo-Yang Hsu; Wei-Lun Hung; Chi-Tang Ho; Irene H. Cheng; Lucy Sun Hwang

Journal of Functional Foods (Jun 2015)

Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice

Bo-Yang Hsu,
Wei-Lun Hung,
Chi-Tang Ho,
Irene H. Cheng,
Lucy Sun Hwang

Affiliations

Bo-Yang Hsu: Department of Food and Beverage Management, University of Kang Ning, No. 188, Section 5, Anzhong Road, Tainan 709, Taiwan
Wei-Lun Hung: Graduate Institute of Food Science and Technology, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 106, Taiwan
Chi-Tang Ho: Department of Food Science, Rutgers University, New Brunswick, NJ, USA
Irene H. Cheng: Institute of Brain Science, National Yang-Ming University, No. 155, Section 2, Li-Nong Street, Taipei 112, Taiwan
Lucy Sun Hwang: Graduate Institute of Food Science and Technology, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 106, Taiwan; Department of Bioscience Technology, Chung-Yuan Christian University, No. 200, Chung-Pei Road, Chung-Li City 320, Taiwan; Corresponding author. Graduate Institute of Food Science and Technology, National Taiwan University, No.1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan. Tel.: +886 2 23629984; fax: +886 2 33664113.

Journal volume & issue: Vol. 16
pp. 378 – 385

Abstract

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Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation between the formation of endogenous trans fatty acids (TFA) and the progression of AD. Thus, the goal of this research was to study the difference of trans-arachidonic acid (TAA) composition of brain and hippocampus between J20 mice (AD mouse model) and B6 mice (wild type control). Our results showed that the endogenous TAA (8-trans-C20:4) of brain and hippocampus in 9 months old J20 mice was significantly higher than B6 mice which indicated that there was a positive relationship between the formation of endogenous TAA and AD. In addition, this study also revealed that sesamol and ferulic acid could reduce the formation of 8-trans-C20:4. Thus, they might be employed as potential functional food ingredients for the prevention of AD.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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