Thelenota ananas saponin extracts attenuate the atherosclerosis in apoE−/− mice by modulating lipid metabolism

Qi-An Han; Shiliang Jia; Kaifeng Li; Yinqiang Sui; Hui Hong; Xiuping Dong; Yongkang Luo; Beiwei Zhu

Journal of Functional Foods (Jul 2019)

Thelenota ananas saponin extracts attenuate the atherosclerosis in apoE−/− mice by modulating lipid metabolism

Qi-An Han,
Shiliang Jia,
Kaifeng Li,
Yinqiang Sui,
Hui Hong,
Xiuping Dong,
Yongkang Luo,
Beiwei Zhu

Affiliations

Qi-An Han: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Shiliang Jia: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Kaifeng Li: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Yinqiang Sui: School of Life Science, Tsinghua University, Beijing 100084, China
Hui Hong: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Xiuping Dong: School of Food Science and Technology, Dalian Polytechnic University, National Engineering Research Center of Seafood, Dalian 116034, China
Yongkang Luo: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Corresponding authors at: Beijing Advanced Innovation Center for Food Nutrition and Human Health, No. 17 Tsinghua East Road, Beijing 100083, China (B. Zhu and Y. Luo). Dalian Polytechnic University, No. 1 Qinggongyuan, Dalian 116034, China (B. Zhu)
Beiwei Zhu: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; School of Food Science and Technology, Dalian Polytechnic University, National Engineering Research Center of Seafood, Dalian 116034, China; Corresponding authors at: Beijing Advanced Innovation Center for Food Nutrition and Human Health, No. 17 Tsinghua East Road, Beijing 100083, China (B. Zhu and Y. Luo). Dalian Polytechnic University, No. 1 Qinggongyuan, Dalian 116034, China (B. Zhu)

Journal volume & issue: Vol. 58
pp. 238 – 247

Abstract

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As one of the most nutrient-rich marine species, Thelenota ananas has various effects, but its antiatherosclerosis activity has yet to be plumbed in depths. In this work, T. ananas saponin extracts were used to assess the effect on atherosclerosis development in the apoE−/− mice. In detail, the saponin treated groups clearly showed an inhibitory effect on the size of aortic atheromatous plaque, and the levels of serum lipid and inflammatory cytokines compared with the atherosclerosis model mice. Interestingly, the saponin extracts decreased the lipid profiles and oxidation in the visceral fat, and markedly altered the expressions of key proteins related to lipid synthesis and inflammation in the liver. Furthermore, saponin extracts promoted the diversity of the fecal bacterial colonies which has a close correlation with lipid metabolism. The results above revealed that T. ananas saponin extracts may be a beneficial natural resource for the prevention of atherosclerosis by modulating lipid metabolism.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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