Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans

Zhiying Hou; Deqi Zhu; Xinchang Gao; Li Zhao; Hui Yang; Qiong Wang; Yufen Zhao; Ning Wang

Journal of Functional Foods (Nov 2023)

Antiaging and antioxidative effects of water extract of Zizyphus jujuba Mill on Caenorhabditis elegans

Zhiying Hou,
Deqi Zhu,
Xinchang Gao,
Li Zhao,
Hui Yang,
Qiong Wang,
Yufen Zhao,
Ning Wang

Affiliations

Zhiying Hou: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Deqi Zhu: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China
Xinchang Gao: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China
Li Zhao: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China
Hui Yang: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China
Qiong Wang: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China; Sino-Portugal TCM International Cooperation Center, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China
Yufen Zhao: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo 315211, China; Corresponding authors at: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.
Ning Wang: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Corresponding authors at: Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.

Journal volume & issue: Vol. 110
p. 105829

Abstract

Read online

Zizyphus jujuba Mill is a typical food-medicine homology in China, and the adage of “three jujubes a day, longevity” highlights its potential antiaging properties. However, its antiaging effect and mechanism have been poorly explored. In this study, Caenorhabditis elegans was utilized to investigate the antiaging effects and underlying mechanisms of the active components of jujube water extract (ZJME). We discovered that ZJME is rich in polysaccharides (264.15 mg/g), polyphenols (9.29 mg/g), cAMP and other components with antioxidant effects. ZJME significantly prolonged the average and maximum lifespan (31 % and 14 %) of nematodes under oxidative stress conditions. ZJME reduced the release of ROS and RNS by 44 % and 22 %, and increased the activity of the antioxidant enzymes SOD by 18 % (P < 0.01) and CAT by 55 % (P < 0.05). qRT-PCR analysis revealed that ZJME regulated the AMPK and MAPK pathway while inhibiting the IIS pathway to enhance the antioxidant defense system.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords