New phenolic compounds from Vitex negundo var. heterophylla and their antioxidant and NO inhibitory activities

Ping Hu; Dahong Li; Kaibo Wang; Hao Wang; Zihou Wang; Zhanlin Li; Huiming Hua

Journal of Functional Foods (Dec 2015)

New phenolic compounds from Vitex negundo var. heterophylla and their antioxidant and NO inhibitory activities

Ping Hu,
Dahong Li,
Kaibo Wang,
Hao Wang,
Zihou Wang,
Zhanlin Li,
Huiming Hua

Affiliations

Ping Hu: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Dahong Li: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Kaibo Wang: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Hao Wang: College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China
Zihou Wang: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Zhanlin Li: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding authors. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Tel.: +86 024 23986465; fax: +86 024 23986465.
Huiming Hua: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Corresponding authors. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Tel.: +86 024 23986465; fax: +86 024 23986465.

Journal volume & issue: Vol. 19
pp. 174 – 181

Abstract

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Four new phenolic compounds, vitexnegheteroins A–D (1–4), were isolated from the seeds of Vitex negundo var. heterophylla, together with eight known compounds. Their structures were established on the basis of extensive 1D and 2D NMR experiments, as well as their mass spectroscopic data. The absolute configuration of compound 4 was determined by comparing its experimental CD spectrum with that calculated by the time-dependent density functional theory (TDDFT) method. The antioxidant and anti-inflammatory activities of these phenolics were also evaluated. Most of the compounds showed strong ABTS radical scavenging activities and all the tested isolates exhibited inhibitory effects on lipopolysaccharide-induced NO production in murine microglial BV-2 cells. The bioactive studies supported the traditional use of this edible aromatic plant and disclosed the potency of it to be developed as new antioxidant and anti-inflammatory functional food.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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