Tibetan tea reduces obesity brought on by a high‐fat diet and modulates gut flora in mice

Gang He; Tangcong Chen; Lifen Huang; Yiyuan Zhang; Yanjiao Feng; Qijun Liu; Xiaojing Yin; Shaokui Qu; Chen Yang; Jianghong Wan; Li Liang; Jun Yan; Wei Liu

doi:10.1002/fsn3.3607

Food Science & Nutrition (Oct 2023)

Tibetan tea reduces obesity brought on by a high‐fat diet and modulates gut flora in mice

Gang He,
Tangcong Chen,
Lifen Huang,
Yiyuan Zhang,
Yanjiao Feng,
Qijun Liu,
Xiaojing Yin,
Shaokui Qu,
Chen Yang,
Jianghong Wan,
Li Liang,
Jun Yan,
Wei Liu

Affiliations

Gang He: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Tangcong Chen: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Lifen Huang: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Yiyuan Zhang: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Yanjiao Feng: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Qijun Liu: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Xiaojing Yin: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Shaokui Qu: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Chen Yang: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Jianghong Wan: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Li Liang: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Jun Yan: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China
Wei Liu: Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University Chengdu China

DOI: https://doi.org/10.1002/fsn3.3607
Journal volume & issue: Vol. 11, no. 10
pp. 6582 – 6595

Abstract

Read online

Abstract It has been shown that Tibetan tea (TT) inhibits obesity and controls lipid metabolism. The fundamental processes by which TT prevents obesity are yet entirely unknown. Consequently, this research aimed to ascertain if TT may prevent obesity by modifying the gut flora. Our research demonstrated that TT prevented mice from gaining weight and accumulating fat due to the high‐fat diet (HFD), decreased levels of blood total cholesterol (TC), triglycerides (TG), and low‐density lipoprotein cholesterol (LDL‐C), and raised levels of high‐density lipoprotein cholesterol (HDL‐C). Adipogenesis‐related genes such as acetyl‐Coenzyme A carboxylase 1 (ACC1, LOC107476), fatty acid synthase (Fas, LOC14104), sterol regulatory element‐binding protein‐1c (SREBP‐1c, LOC20787), CCAAT/enhancer‐binding protein α (C/EBPα, LOC12606), stearoyl‐CoA desaturase 1 (SCD1, LOC20249), and peroxisome proliferator‐activated receptor γ (PPARγ, LOC19016) had their expression downregulated by lowering the Firmicutes/Bacteroidetes (F/B) ratio and controlling the number of certain gut bacteria. TT also alleviated HFD‐induced abnormalities of the gut microbiota. The Muribaculaceae, Lachnospiraceae NK4A136_group, Alistipes, and Odoribacter families were identified as the major beneficial gut microorganisms using Spearman's correlation analysis. Fecal microbiota transplantation (FMT) demonstrated that TT's anti‐obesity and gut microbiota‐modulating benefits might be transmitted to mice on an HFD, demonstrating that one of TT's targets for preventing obesity is the gut microbiota. TT also increased the amount of short‐chain fatty acids (SCFAs) in the feces, including acetic, propionic, and butyric acids. These results indicate the possible development of TT as a prebiotic to combat obesity and associated disorders. These results suggest that TT may act as a prebiotic against obesity and its associated diseases.

Published in Food Science & Nutrition

ISSN: 2048-7177 (Online)
Publisher: Wiley
Country of publisher: United States
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://onlinelibrary.wiley.com/journal/20487177

About the journal

Abstract

Keywords