A NEW AND CONCISE SYNTHESIS OF 3-HYDROXYLATED 3-ARYLISOINDOLINONES NOUVELLE TECHNIQUE D'ASSEMBLAGE DE 3-ARYLISOINDOLINONES HYDROXYLEES EN POSITION 3
MAGALI LORION,
AXEL COUTURE,
PIERRE GRANDCLAUDON
Affiliations
MAGALI LORION
Université Lille Nord de France, F-59000 Lille, France; USTL, Laboratoire de Chimie Organique Physique, EA CMF 4478, Bâtiment C3(2), F-59655 Villeneuve d'Ascq, France
AXEL COUTURE
Université Lille Nord de France, F-59000 Lille, France; CNRS, UMR 8181 'UCCS', F-59655 Villeneuve d'Ascq, France
PIERRE GRANDCLAUDON
Université Lille Nord de France, F-59000 Lille, France; USTL, Laboratoire de Chimie Organique Physique, EA CMF 4478, Bâtiment C3(2), F-59655 Villeneuve d'Ascq, France
A new technique for the assembly of diversely substituted 3-hydroxy(alkoxy)-3-arylisoindolinones has been developed. This new synthetic route is based upon the anionic cyclization of suitably substituted halogenoaroyl acylamines as the key step and gives access to a variety of highly functionalized models.
