Extra virgin coconut oil (Cocos nucifera L.) exerts anti-obesity effect by modulating adiposity and improves hepatic lipid metabolism, leptin and insulin resistance in diet-induced obese rats

Maria Helena Araújo de Vasconcelos; Renata Leite Tavares; Emanuel Ubaldino Torres Junior; Victor Augusto Mathias Dorand; Kamila Sabino Batista; Lydiane Tavares Toscano; Alexandre Sergio Silva; Angela Maria Tribuzy de Magalhães Cordeiro; Bruno Ranieri Lins de Albuquerque Meireles; Rubens da Silva Araujo; Adriano Francisco Alves; Jailane de Souza Aquino

Journal of Functional Foods (Jul 2022)

Extra virgin coconut oil (Cocos nucifera L.) exerts anti-obesity effect by modulating adiposity and improves hepatic lipid metabolism, leptin and insulin resistance in diet-induced obese rats

Maria Helena Araújo de Vasconcelos,
Renata Leite Tavares,
Emanuel Ubaldino Torres Junior,
Victor Augusto Mathias Dorand,
Kamila Sabino Batista,
Lydiane Tavares Toscano,
Alexandre Sergio Silva,
Angela Maria Tribuzy de Magalhães Cordeiro,
Bruno Ranieri Lins de Albuquerque Meireles,
Rubens da Silva Araujo,
Adriano Francisco Alves,
Jailane de Souza Aquino

Affiliations

Maria Helena Araújo de Vasconcelos: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Renata Leite Tavares: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Emanuel Ubaldino Torres Junior: Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Victor Augusto Mathias Dorand: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Kamila Sabino Batista: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Lydiane Tavares Toscano: Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Laboratory of Physical Training Studies Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Alexandre Sergio Silva: Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Laboratory of Physical Training Studies Applied to Performance and Health, Department of Physical Education, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Angela Maria Tribuzy de Magalhães Cordeiro: Department of Food Technology, Center for Technology and Regional Development, Federal University of Paraíba (UFPB), João Pessoa 58051-900, Paraíba, Brazil
Bruno Ranieri Lins de Albuquerque Meireles: Department of Food Engineering, Academic Unit of Food Technology, Federal University of Campina Grande (UFCG), Pombal 58840-000, Paraíba, Brazil
Rubens da Silva Araujo: Laboratory of General Pathology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Adriano Francisco Alves: Laboratory of General Pathology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil
Jailane de Souza Aquino: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Paraíba, Brazil; Corresponding author at: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-900, Paraíba, Brazil.

Journal volume & issue: Vol. 94
p. 105122

Abstract

Read online

Few studies have addressed the effect of extra virgin coconut oil (E-VCO) in obesity. Therefore, this study investigated the anti-adiposity effect of E-VCO focusing on biochemical parameters and liver health of obese rats. E-VCO contains caprilyc, capric and lauric fatty acids and rutin, 3,4-dihydroxybenzoic acid, salicylic acid as major phenolic compounds. A total of 32 male Wistar rats were randomized into four groups: healthy; healthy treated with E-VCO; obese; obese treated with E-VCO. The rats consumed a control or cafeteria diet for 16 weeks. The treated groups received 3,000 mg/kg of E-VCO via gavage. E-VCO reduced body mass and adiposity index and improved hormonal parameters. E-VCO also decreased the accumulation of liver fat, hepatic cholesterol and triglyceride levels, increased faecal cholesterol excretion and decreased faecal triglycerides excretion. E-VCO had an anti-adiposity effect and reversed changes in liver and adipose tissues induced by obesity with improvements in metabolic parameters.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords