Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice

S. Xu; Y. Dou; B. Ye; Q. Wu; Y. Wang; M. Hu; F. Ma; X. Rong; J. Guo

Journal of Functional Foods (Nov 2017)

Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice

S. Xu,
Y. Dou,
B. Ye,
Q. Wu,
Y. Wang,
M. Hu,
F. Ma,
X. Rong,
J. Guo

Affiliations

S. Xu: Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou, China
Y. Dou: School of Chinese Meteria Medica, Guangzhou University of Chinese Medicine, Guangzhou, China
B. Ye: Department of Nursing, Medical College of Jiaying University, Meizhou 514031, China
Q. Wu: Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou, China
Y. Wang: Infinitus Chinese Herbal Immunity Research Centre, Guangzhou, China
M. Hu: Infinitus Chinese Herbal Immunity Research Centre, Guangzhou, China
F. Ma: Infinitus Chinese Herbal Immunity Research Centre, Guangzhou, China
X. Rong: Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou, China; Corresponding authors at: Guangdong Metabolic Diseases Research Centre of Integrated Chinese, and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China.
J. Guo: Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou, China; Corresponding authors at: Guangdong Metabolic Diseases Research Centre of Integrated Chinese, and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Journal volume & issue: Vol. 38
pp. 545 – 552

Abstract

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Ectopic lipid accumulation and low-grade chronic inflammation are critical pathogenesis of insulin resistance development. Ganoderma lucidum is a traditional Chinese herb for balancing energy homeostasis. In this research, we determined the effects of G. lucidum polysaccharides (GLP) on high-fat diet (HFD)-induced insulin resistant mice. We observed that GLP treatment decreased plasma insulin concentration and reversed HFD-induced systemic insulin resistance. Meanwhile, GLP ameliorated low-grade chronic inflammation, inducing lipolysis in adipose tissues. GLP decreased plasma triglyceride and non-esterified fatty acid outflux by suppressing mRNA expressions of hormone-sensitive lipase, fatty acid binding protein 4, tumor necrosis factor-α, and interleukin-6 in epididymal fat. Finally, GLP treatment suppressed ectopic lipid accumulation in peripheral tissues and hepatic insulin-regulated lipogenesis. GLP also regulated composition of gut microbiota implicated in type 2 diabetes mellitus development.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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