ANTIPLASMODIAL AND ANTISALMONELLA ACTIVITIES OF PHENOLIC COMPOUND FROM ROUREA COCCINEA BENTH (CONNARACEAE)
BASILE GOUETI ,
WILLIAM FEUDJOU ,
BÉNÉDICTA KPADONOU-KPOVIESSI ,
BARDIEU ATCHADE ,
SERONDO UWIKUNDA ,
LÉON AHOUSSI ,
JOACHIM GBENOU ,
SALOMÉ KPOVIESSI
Affiliations
BASILE GOUETI
University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin and Institute of Medical Research and Medicinal Plants Studies, CRPMT, P.O. Box 13033, Yaoundé, Cameroon
WILLIAM FEUDJOU
Institute of Medical Research and Medicinal Plants Studies, CRPMT, P.O. Box 13033, Yaoundé, Cameroon
BÉNÉDICTA KPADONOU-KPOVIESSI
University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin
BARDIEU ATCHADE
University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin
SERONDO UWIKUNDA
Higher Pedagogical Institute of Bukavu, Department of Chemistry Democratic Republic of Congo
LÉON AHOUSSI
University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin
JOACHIM GBENOU
University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin
SALOMÉ KPOVIESSI
University of Abomey-Calavi (UAC), Faculty of Sciences and Techics (FAST), (LaCOPS), (LAPHE), 01 BP: 4166 Cotonou, Benin
The leaves extract of Rourea coccinea was fractionated, following the bioguided method, to give one phenolic compound named 1-caffeoylquinic acid lactone (1-CQL) (1), isolated from this plant for the first time, and the 3-O-β-D-glucopyranoside of stigmasterol (2). The structure of these compounds was determined. The Minimum Inhibitory Concentrations (MIC) for antisalmonella activity was up to 2000 µg·mL-1 for extract and fractions, and up to 500 µg·mL-1 for compound 1. The half-inhibitory Concentration (IC50) values against Plasmodium falciparum PfDd2 was 92.56 µg·mL-1 for extract and 31.24 to 77.21 µg·mL-1 for fractions. Compound 1 exhibited on the same strain an antiplasmodial activity with an IC50 value of 8.58 µg·mL-1. These results justify the use of this plant in Beninese pharmacopeia for the treatment of several diseases such as malaria.
