Rapid modulation of lipid metabolism in C57BL/6J mice induced by eicosapentaenoic acid-enriched phospholipid from Cucumaria frondosa

Lingyu Zhang; Dan Wang; Min Wen; Lei Du; Changhu Xue; Jingfeng Wang; Jie Xu; Yuming Wang

Journal of Functional Foods (Jan 2017)

Rapid modulation of lipid metabolism in C57BL/6J mice induced by eicosapentaenoic acid-enriched phospholipid from Cucumaria frondosa

Lingyu Zhang,
Dan Wang,
Min Wen,
Lei Du,
Changhu Xue,
Jingfeng Wang,
Jie Xu,
Yuming Wang

Affiliations

Lingyu Zhang: College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province, PR China
Dan Wang: College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province, PR China
Min Wen: College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province, PR China
Lei Du: Faculty of Fisheries Sciences, Hokkaido University, 3-1-1 Minato-Cho, Hakodate, Hokkaido O41-8611, Japan
Changhu Xue: College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province, PR China
Jingfeng Wang: College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province, PR China
Jie Xu: College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province, PR China; Corresponding authors at: Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province 266003, PR China.
Yuming Wang: College of Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province, PR China; Corresponding authors at: Food Science and Engineering, Ocean University of China, No. 5 Yushan Road, Qingdao, Shandong Province 266003, PR China.

Journal volume & issue: Vol. 28
pp. 28 – 35

Abstract

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Recent study demonstrated that dietary eicosapentaenoic acid (EPA) could alleviate metabolism disorders. However, the onset time of EPA-enriched phospholipid (EPA-PL) on lipid metabolism was rarely been reported. The aim of the present study was to evaluate the time-dependent changes in lipid profile and genes of lipometabolism induced by EPA-PL from Cucumaria frondosa. Male C57BL/6J mice were fed a standard diet with or without EPA-PL for 3, 7, or 14 days. Additionally, we examined gene expression 1 week after removing EPA-PL from the diet. Our results indicated that 3-day EPA-PL supplementation significantly increased the expression of genes related to β-oxidation (UCP2, Ehhadh, Acaa1) in the liver and epididymal adipose tissue, whereas no differences were observed in the mRNA expression of selected genes between groups 1 week after EPA-PL removal. It is concluded that EPA-PL served as a rapid regulator of fat burning and could be a functional food for obesity disorders.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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