Potential of trace elements as supplements for the metabolic control of Type 2 Diabetes Mellitus: A systematic review

Abstract

The objective of this review was to understand the role of trace elements in the form of supplements in metabolic control of Type 2 Diabetes Mellitus (T2DM). A systematic research was performed following PRISMA recommendations. Although 3236 studies were identified, only 18 studies composed of nine animal studies and nine clinical studies were included in this review. The included trace elements were Chromium (Cr), Selenium (Se), Zinc (Zn) and Vanadium (V). The time, dose and type of supplement varied among the studies. Se, Cr, Zn and V improved glycemic profile and antioxidant status while Se, Cr and Zn affected lipid profile. Se and Zn supplementation improved endothelial function. Also, Se modified inflammatory profile. In general, cautious supplementation of trace elements promotes the metabolic control of T2DM.

Keywords

• Glycemic profile
• Oxidative stress
• Lipid profile
• Inflammation
• Oligo-elements