Memory enhancement by administration of ginger (Zingiber officinale) extract on morphine-induced memory impairment in male rats

Abstract

To study the chronic treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the passive avoidance learning (PAL) and memory in rat. Methods: The rats were divided into eight groups. On the training trial, the mice received an electric shock when the animals were entered into the dark compartment. Twenty-four hours later, 30 min after treatment, the STL (step-through latency) and TDC (total time in dark compartments) was recorded and defined as the retention trial. Results: The time latency in morphine-treated group was lower than control (P<0.001). Treatment of the animals by 100 and 200 mg/kg of ginger extract before the training trial increased the time latency at 24 hours after the training trial (P<0.01 and P<0.001). Administration of both 100 and 200 mg/kg doses of the extract in morphine received animal groups before retention trials also increased the time latency than the morphine-treated group groups (P<0.001). Conclusion: The results revealed that the ginger extract attenuated morphine-induced memory impairment.

Keywords

• Memory
• Learning
• Zingiber officinale
• Ginger
• Morphine
• Rat