Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides

Jingjing Dong; Shen Wang; Xiaoyao Yin; Min Fang; Zhiyong Gong; Yongning Wu

Food Science and Human Wellness (Nov 2022)

Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides

Jingjing Dong,
Shen Wang,
Xiaoyao Yin,
Min Fang,
Zhiyong Gong,
Yongning Wu

Affiliations

Jingjing Dong: Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Shen Wang: Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Xiaoyao Yin: Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Min Fang: Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Zhiyong Gong: Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China; Corresponding author at: College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Yongning Wu: HC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, China

Journal volume & issue: Vol. 11, no. 6
pp. 1539 – 1543

Abstract

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In this paper, the antihypertension effect of rice peptide (RP) was studied. With spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) as the research objects, RP disposable gastric and long-term gastric irrigation experiments were carried out and systolic blood pressure (SBP) was measured. At the end of the long-term gastric irrigation experiment, the content of nitric oxide (NO), angiotensin-converting enzyme (ACE), angiotensin II (Ang II) and renin in the plasma and the activity of ACE were determined. The results showed that RP could reduce systolic pressure of SHR and had time-dose dependence while high-dose RP significantly reduced systolic pressure by 24.6 and 17.2 mmHg, respectively after a single and long-term gastric irrigation test. RP also could inhibit the activity of ACE and increase the release of NO. These results suggested that the decompression mechanism of RP is likely to be related to the regulation of the renin-angiotensin system (RAS) and NO.

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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