Research Progress of Mitochondrial-Mediated Docosahexaenoic Acid (DHA) Antioxidation

Xiaoting SUN; Le XU; Baoping XIAO; Dongyue CUI; Jingwen LIU; Jian LI; Jingyu LIN; Guiling LI

doi:10.13386/j.issn1002-0306.2021060190

Shipin gongye ke-ji (May 2022)

Research Progress of Mitochondrial-Mediated Docosahexaenoic Acid (DHA) Antioxidation

Xiaoting SUN,
Le XU,
Baoping XIAO,
Dongyue CUI,
Jingwen LIU,
Jian LI,
Jingyu LIN,
Guiling LI

Affiliations

Xiaoting SUN: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Le XU: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Baoping XIAO: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Dongyue CUI: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Jingwen LIU: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Jian LI: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Jingyu LIN: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Guiling LI: College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China

DOI: https://doi.org/10.13386/j.issn1002-0306.2021060190
Journal volume & issue: Vol. 43, no. 10
pp. 475 – 481

Abstract

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Docosahexaenoic acid (DHA) is an essential omega-3 polyunsaturated fatty acid (PUFA) for human body, which is highly rich in deep sea fish oil and marine microalgae. Mitochondria are the energy factory of cells. Mitochondrial functions and biogenesis can be regulated by DHA which exhibits antioxidation, anti-inflammatory and anti-cancer activities. This article reviews the research progress of mitochondrial-mediated DHA antioxidation and the possible underlying mechanism. The effects of DHA in eliminating reactive oxygen species (ROS) and regulating mitochondrial biogenesis and functions, as well as the microRNA-mediated DHA antioxidant epigenetic mechanism are addressed, which may provide evidence for better DHA product exploration and application.

Published in Shipin gongye ke-ji

ISSN: 1002-0306 (Print)
Publisher: The editorial department of Science and Technology of Food Industry
Country of publisher: China
LCC subjects: Technology: Chemical technology: Food processing and manufacture
Website: http://www.spgykj.com/indexen.htm

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Abstract

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