Can resveratrol supplementation affect biomarkers of inflammation and oxidative stress? An umbrella meta-analysis

Abstract

Several meta-analyses exist in supporting the positive effects of resveratrol on inflammatory and oxidative stress biomarkers; however, the finding of some studies is inconsistent. Therefore, the objective of the current study was to investigate the effects of resveratrol on inflammatory and oxidative stress biomarkers in adults. Up until April 2022, we conducted a thorough and systematic search in PubMed, Scopus, Web of Science, Embase, and Google Scholar. Our results from 15 meta-analyses indicated that the resveratrol supplementation meaningfully decrease serum CRP (ES = −0.38, 95 % CI: −0.47, −0.30; p < 0.001) and TNF-α (ES = −0.32; 95 % CI: −0.54, −0.11; p = 0.004). However, the effect of resveratrol on IL-6, TAC, GPx, and SOD activity was not significant. The current umbrella meta-analysis supports the alleviating effects of resveratrol on inflammatory markers but does not suggest any beneficial effect on oxidative stress biomarkers. Therefore, to support this evidence, larger and well-designed trials are required.

Keywords

• Resveratrol
• Inflammation
• Oxidative stress
• Meta-analysis