<i>Aspergillus-</i>Derived Cellulase Preparation Exhibits Prebiotic-like Effects on Gut Microbiota in Rats

Abstract

Aspergillus-derived cellulase, which is involved in the production of Aspergillus-fermented foods, has been employed in the food and animal feed industries. However, the effect of dietary Aspergillus cellulase on health is poorly understood. Previously, we discovered that supplemental Aspergillus-derived protease and lipase preparations had substantial bifidogenic effects on rats fed a high-fat diet. Therefore, this study reports on the effects of a 0.1% dietary Aspergillus-derived cellulase preparation (CEL) on the gut microbiota of rats fed a high-fat diet. Gene sequencing analysis of 16S rRNA revealed that CEL treatment markedly affected the microbiota profiles of the cecal contents (p Bifidobacterium and Lactobacillus, at the genus level (28- and 5-fold, respectively, p p Collinsella and Enterococcus, but decreased the RA of Oscillospira, Dorea and Coprobacillus (p Bifidobacterium and Lactobacillus abundance.

Keywords

• fermentation foods
• <i>Aspergillus</i>
• cellulase
• <i>Bifidobacterium</i>
• <i>Lactobacillus</i>
• prebiotic