npj Vaccines (Mar 2021)

The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization

  • Jing Zou,
  • Xuping Xie,
  • Camila R. Fontes-Garfias,
  • Kena A. Swanson,
  • Isis Kanevsky,
  • Kristin Tompkins,
  • Mark Cutler,
  • David Cooper,
  • Philip R. Dormitzer,
  • Pei-Yong Shi

DOI
https://doi.org/10.1038/s41541-021-00313-8
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 4

Abstract

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Abstract Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7–2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.