Passiflora tenuifila Killip: Assessment of chemical composition by 1H NMR and UPLC-ESI-Q-TOF-MSE and its bioactive properties in a rotenone-induced rat model of Parkinson’s disease

Abstract

Passiflora tenuifila Killip is a wild species, with no studies regarding to functional properties. The objective of this work was to evaluate the chemical composition, including NMR and UPLC, toxicity and functional effect in a Parkinsonism model. The fruits (peel, pulp, and seed) were crushed, lyophilized and characterized. The subchronic toxicity was evaluated in Wistar rats during 90 days, and the Parkinsonism symptoms were induced by rotenone and after treated with P. tenuifila daily doses during 21 days. Composition results indicated a high total dietary fiber content, total polyphenols, and antioxidant activity. The subchronic toxicity results showed that garlic passion fruit did not present signs of toxicity. In the Parkinsonism model, the tests allow to indicate that the consumption of garlic passion fruit causes an improvement and possible effect of recovery of the damages induced by the rotenone, being these effects of improvement proportional to the consumption.

Keywords

• Parkinsonism induced model
• Garlic passion fruit
• Antioxidant
• Phenolic compounds