Renoprotective effect of stevia residue extract on adenine-induced chronic kidney disease in mice

Arshad Mehmood; Liang Zhao; Muhammad Ishaq; Oumeddour Dounya Zad; Lei Zhao; Chengtao Wang; Muhammmad Usman; Yunhe Lian; Meili Xu

Journal of Functional Foods (Sep 2020)

Renoprotective effect of stevia residue extract on adenine-induced chronic kidney disease in mice

Arshad Mehmood,
Liang Zhao,
Muhammad Ishaq,
Oumeddour Dounya Zad,
Lei Zhao,
Chengtao Wang,
Muhammmad Usman,
Yunhe Lian,
Meili Xu

Affiliations

Arshad Mehmood: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing 100048, China
Liang Zhao: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing 100048, China
Muhammad Ishaq: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing 100048, China
Oumeddour Dounya Zad: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing 100048, China
Lei Zhao: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing 100048, China; Corresponding authors at: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China.
Chengtao Wang: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing 100048, China; Corresponding authors at: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China.
Muhammmad Usman: Beijing Advance Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, School of Food and Chemical Technology, Beijing Technology and Business University, Beijing 100048, China
Yunhe Lian: Chenguang Biotech Group Co. Ltd., Handan 057250, China
Meili Xu: Chenguang Biotech Group Co. Ltd., Handan 057250, China

Journal volume & issue: Vol. 72
p. 103983

Abstract

Read online

The present study was performed to explore the renoprotective potential of a stevia residue extract (STRE) on a mouse model of adenine-induced chronic kidney disease (CKD). The mice were divided into five groups (n = 10): control, model, Po, STRE-1, and STRE-2. Adenine (0.20% in the normal diet for 3 weeks) was used to induce CKD. Allopurinol and STRE markedly restored the balance of functional, oxidative, and inflammatory biomarkers and improved the renal histopathology and ultrastructure compared to the Mod group. Moreover, STRE also attenuated the renal fibrosis by suppressing the TGF-β1/Smad and Wnt/β-catenin signalling pathways and improved the gut microbiota composition. The results of present study confirmed that STRE has a potential to attenuate renal injury caused by adenine and may be used to develop of nutraceutical products, warranting further studies to elucidate beneficial effects of STRE.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords