Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes

Antonio Hernández-Mijares; Celia Bañuls; Susana Rovira-Llopis; Ángeles Álvarez; Samuel Orden; Olalla Rubio-Puchol; Víctor M. Víctor; Milagros Rocha

Journal of Functional Foods (Oct 2015)

Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes

Antonio Hernández-Mijares,
Celia Bañuls,
Susana Rovira-Llopis,
Ángeles Álvarez,
Samuel Orden,
Olalla Rubio-Puchol,
Víctor M. Víctor,
Milagros Rocha

Affiliations

Antonio Hernández-Mijares: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; Department of Medicine, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Corresponding authors. FISABIO-University Hospital Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain. Tel.: +34 961622492; fax: +34 961622492.
Celia Bañuls: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain
Susana Rovira-Llopis: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain
Ángeles Álvarez: CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Department of Pharmacology, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain
Samuel Orden: CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Department of Pharmacology, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain
Olalla Rubio-Puchol: Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain
Víctor M. Víctor: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Department of Physiology, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Corresponding authors. FISABIO-University Hospital Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain. Tel.: +34 961622492; fax: +34 961622492.
Milagros Rocha: Foundation for the Promotion of Healthcare and Biomedical Research in the Valencian Community (FISABIO), Avda Cataluña 21, 46020 Valencia, Spain; Service of Endocrinology, University Hospital Dr. Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Corresponding authors. FISABIO-University Hospital Dr. Peset, Av. Gaspar Aguilar 90, 46017 Valencia, Spain. Tel.: +34 961622492; fax: +34 961622492.

Journal volume & issue: Vol. 18
pp. 598 – 607

Abstract

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The anti-diabetic properties of an inositol-enriched beverage (IEB) on the endothelial function and redox status in diabetic subjects were assessed. This was a 12-week, double-blind randomized controlled trial employing thirty-eight diabetic subjects that were divided into two intervention groups: one receiving an IEB and the other a sucrose-enriched beverage. Subjects consuming IEB exhibited a significant decrease in triacylglycerol (8.82%) and HbA1c (4.53%) levels. Continuous glucose monitoring revealed a significant net reduction of 2.51 and 7.11% during postprandial and overnight fasting periods after consumption of IEB, respectively. Moreover, IEB improved endothelial function by reducing P-selectin levels and leucocyte–endothelium interactions, as there was an increase in rolling velocity and a reduction in polymorphonuclear leucocyte adhesion and induced a significant diminution in the generation of ROS. The present results show that IEB supplementation induces a significant improvement in glycaemic control in diabetic subjects by improving endothelial function and intracellular redox status.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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