A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Po-Hui Yang; Che-Tsung Chan; Ying-Sheng Chang

doi:10.1109/JEDS.2023.3243056

IEEE Journal of the Electron Devices Society (Jan 2023)

A Flexible Printed Circuit Board-Based ZnO Enzymatic Uric Acid Potentiometric Biosensor Measurement and Characterization

Po-Hui Yang,
Che-Tsung Chan,
Ying-Sheng Chang

Affiliations

Po-Hui Yang: ORCiD; Graduate School of Electronic Engineering, National Yunlin University of Science and Technology, Douliou, Taiwan
Che-Tsung Chan: Graduate School of Electronic Engineering, National Yunlin University of Science and Technology, Douliou, Taiwan
Ying-Sheng Chang: ORCiD; Graduate School of Electronic Engineering, National Yunlin University of Science and Technology, Douliou, Taiwan

DOI: https://doi.org/10.1109/JEDS.2023.3243056
Journal volume & issue: Vol. 11
pp. 114 – 121

Abstract

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This study prepared an enzymatic potentiometric uric acid sensor based on zinc oxide (ZnO) and uricase. Also, we develop a potentiometric differential measurement system. We applied Nafion, APTES, and glutaraldehyde to immobilize the enzyme and increase sensitivity to prevent enzyme leakage. Thus, the uric acid sensor was integrated into FPCB which could provide flexibility to the sensor. In the uric acid concentration range of 2 mg/dL-10 mg/dL, we analyzed the characteristics of sensors with the voltage-time measurement system, measuring the average sensitivity, linearity, response time, limit of detection (LOD), and interference effects. The modification of Nafion and uricase improved the performance of the uric acid sensor.

Published in IEEE Journal of the Electron Devices Society

ISSN: 2168-6734 (Online)
Publisher: IEEE
Country of publisher: United States
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering
Website: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=6245494

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