Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry (Dec 2019)

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW (Z)-2-(BENZYLIDENE)-3,4-DIHYDRO-2H-[1,4]-BENZOTHIAZIN-3-ONE D-GLUCOSE DERIVATIVES

  • MOHAMED ELLOUZ ,
  • NADA KHEIRA SEBBAR ,
  • HICHAM ELMSELLEM ,
  • BRAHIM LAKHRISSI ,
  • ZAKARIA MENNANE ,
  • REDA CHAROF ,
  • MARTINE URRUTIGOÎTY ,
  • EL MOKHTAR ESSASSI

Journal volume & issue
Vol. 20, no. 4
pp. 563 – 574

Abstract

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In this work, we are interested in the synthesis of new N-glucosyl 1,4-benzothiazin-3-ones by grafting 5,6-anhydro-3-O-alkyl-1,2-O-isopropylidene-α-D-glucofuranoses onto (Z)-2-benzylidene-3,4-dihydro-2H-1,4-benzothiazin-3-one 1. Deprotection of compounds 3a-c was performed in the mixture CF3COOH-H2O (9/1: v/v) leading to the corresponding compounds 4a-c with good yields. The structures of the synthesized compounds have been characterized using 1H NMR and 13C NMR. Compounds 3a-c and 4a-c were subjected to the evaluation of antibacterial activity. Some compounds tested showed significant activity.

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