The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels

Ljiljana Gojkovic-Bukarica; Jasmina Markovic-Lipkovski; Helmut Heinle; Sanja Cirovic; Jovana Rajkovic; Vladimir Djokic; Vladimir Zivanovic; Ana Bukarica; Radmila Novakovic

Journal of Functional Foods (Jan 2019)

The red wine polyphenol resveratrol induced relaxation of the isolated renal artery of diabetic rats: The role of potassium channels

Ljiljana Gojkovic-Bukarica,
Jasmina Markovic-Lipkovski,
Helmut Heinle,
Sanja Cirovic,
Jovana Rajkovic,
Vladimir Djokic,
Vladimir Zivanovic,
Ana Bukarica,
Radmila Novakovic

Affiliations

Ljiljana Gojkovic-Bukarica: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, Serbia; University Clinical Hospital Center “Dr Dragisa Misovic – Dedinje”, Heroja Milana Tepica 1, 11000 Belgrade, Serbia
Jasmina Markovic-Lipkovski: Institute of Pathology, Medical Faculty, University of Belgrade, Dr Subotica 1, 11129 Belgrade, Serbia
Helmut Heinle: Institute of Physiology, University of Tubingen, Gmelinstrase 5, D-72076 Tubingen, Germany
Sanja Cirovic: Institute of Pathology, Medical Faculty, University of Belgrade, Dr Subotica 1, 11129 Belgrade, Serbia
Jovana Rajkovic: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, Serbia
Vladimir Djokic: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, Serbia
Vladimir Zivanovic: University Clinical Hospital Center “Dr Dragisa Misovic – Dedinje”, Heroja Milana Tepica 1, 11000 Belgrade, Serbia
Ana Bukarica: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, Serbia
Radmila Novakovic: Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, Dr Subotica 1, PO BOX 38, 11129 Belgrade, Serbia; Corresponding author.

Journal volume & issue: Vol. 52
pp. 266 – 275

Abstract

Read online

The effect of resveratrol on vasculature of diabetic animal is not defined. This study was aimed at evaluating how alloxan-induced diabetes alters the relaxation of the isolated rat renal artery (RA) to resveratrol and determining whether prolong hyperglycemia modifies the expression of potassium (K) channels in the wall of RA. Diabetes reduced the sensitivity to resveratrol in RA. According to K channel blocker affinity, it seems that different subtype of K channels were involved in the resveratrol-induced relaxation of RA of normal rats and only voltage-sensitive Kv1 channels took part in the resveratrol effect on the RA of diabetic rats. Endothelial dysfunction developed during diabetes led to down-regulation of the expression of almost all tested K channels, while up-regulation of Kv1.3 channel expression was only noticeable. Having in mind that Kv1.3 channels have a prominent role in insulin signalling, these results suggest renovascular protective effect of resveratrol in diabetes.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords