Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

Yang Xu; Ling-Zhi Li; Qian Cong; Wei Wang; Xiao-Li Qi; Ying Peng; Shao-Jiang Song

Journal of Functional Foods (May 2017)

Bioactive lignans and flavones with in vitro antioxidant and neuroprotective properties from Rubus idaeus rhizome

Yang Xu,
Ling-Zhi Li,
Qian Cong,
Wei Wang,
Xiao-Li Qi,
Ying Peng,
Shao-Jiang Song

Affiliations

Yang Xu: Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Ling-Zhi Li: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Qian Cong: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Wei Wang: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Xiao-Li Qi: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Ying Peng: Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Corresponding authors at: Key Laboratory of Structure-Based Drug Design & Discovery, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China (Y. Peng). Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China (S.-J. Song).
Shao-Jiang Song: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Corresponding authors at: Key Laboratory of Structure-Based Drug Design & Discovery, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China (Y. Peng). Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China (S.-J. Song).

Journal volume & issue: Vol. 32
pp. 160 – 169

Abstract

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Rubus idaeus L. is caneberries from the genus Rubus that have been cultivated as food and herbal medicine, and is known to demonstrate strong antioxidant capability. In the present study, five new lignans, along with 13 known compounds, were isolated from ethanol extracts of R. idaeus rhizomes. An HPLC-MS/MS method was established and successfully applied to quantification of 14 compounds from leaves (LR), fruits (FR) and rhizomes (RR) of R. idaeus. All the compounds showed in vitro antioxidant activities, and three lignans revealed in vitro neuroprotective protective effects against H2O2-induced neurodegeneration in SH-SY5Y cells, the crude RR, LR and FR were found to have both in vitro antioxidant activities and neuroprotective effects.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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