Prenylflavonoids counteract ovariectomy-induced disturbances in rats

Beata Nowak; Agnieszka Matuszewska; Jarosław Popłoński; Anna Nikodem; Jarosław Filipiak; Magdalena Tomanik; Wojciech Dziewiszek; Maciej Danielewski; Kinga Belowska-Bień; Marek Kłobucki; Sandra Sordon; Diana Jędrzejuk; Ireneusz Ceremuga; Małgorzata Trocha; Tomasz Sozański; Tomasz Piasecki; Marek Bolanowski; Ewa Huszcza; Adam Szeląg

Journal of Functional Foods (Nov 2021)

Prenylflavonoids counteract ovariectomy-induced disturbances in rats

Beata Nowak,
Agnieszka Matuszewska,
Jarosław Popłoński,
Anna Nikodem,
Jarosław Filipiak,
Magdalena Tomanik,
Wojciech Dziewiszek,
Maciej Danielewski,
Kinga Belowska-Bień,
Marek Kłobucki,
Sandra Sordon,
Diana Jędrzejuk,
Ireneusz Ceremuga,
Małgorzata Trocha,
Tomasz Sozański,
Tomasz Piasecki,
Marek Bolanowski,
Ewa Huszcza,
Adam Szeląg

Affiliations

Beata Nowak: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland; Corresponding author.
Agnieszka Matuszewska: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
Jarosław Popłoński: Department of Chemistry, Wroclaw University of Environmental and Life Sciences, ul. C.K. Norwida 25, 50-375 Wrocław, Poland
Anna Nikodem: Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, ul. I. Łukasiewicza 7/9, 50-371 Wrocław, Poland
Jarosław Filipiak: Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, ul. I. Łukasiewicza 7/9, 50-371 Wrocław, Poland
Magdalena Tomanik: Cross-divisional Students’ Scientific Circle of Biomechnics, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology, ul. I. Łukasiewicza 7/9, 50-371 Wrocław, Poland
Wojciech Dziewiszek: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
Maciej Danielewski: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
Kinga Belowska-Bień: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
Marek Kłobucki: Department of Chemistry, Wroclaw University of Environmental and Life Sciences, ul. C.K. Norwida 25, 50-375 Wrocław, Poland
Sandra Sordon: Department of Chemistry, Wroclaw University of Environmental and Life Sciences, ul. C.K. Norwida 25, 50-375 Wrocław, Poland
Diana Jędrzejuk: Department and Clinic of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, wyb. Pasteura 4, 50-367 Wrocław, Poland
Ireneusz Ceremuga: Department of Medical Biochemistry, Wroclaw Medical University, ul. T. Chałbińskego 10, 50-367 Wrocław, Poland
Małgorzata Trocha: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
Tomasz Sozański: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland
Tomasz Piasecki: Department of Epizootiology and Clinic of Birds and Exotic Animals, The Faculty of Veterinary Medicine, Wroclaw University of Environment, pl. Grunwaldzki 45, 50-366 Wroclaw, Poland
Marek Bolanowski: Department and Clinic of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, wyb. Pasteura 4, 50-367 Wrocław, Poland
Ewa Huszcza: Department of Chemistry, Wroclaw University of Environmental and Life Sciences, ul. C.K. Norwida 25, 50-375 Wrocław, Poland
Adam Szeląg: Department of Pharmacology, Wroclaw Medical University, ul. J. Mikulicza-Radeckiego 2, 50-345 Wrocław, Poland

Journal volume & issue: Vol. 86
p. 104742

Abstract

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The aim of the study was to investigate in animal model the influence of hops prenylflavonoids on hot flashes and bone loss. Xanthohumol (XN) and hop prenylflavonoids extract (HOP) restored twenty-four-hour variability of tail skin temperature in ovariectomized rats. Additionally XN and HOP increased femoral bone mineral density (BMD) (0.268 ± 0.019 g/cm2 and 0.256 ± 0.013 g/cm2 vs. 0.214 ± 0.015 g/cm2). In micro-computed tomography (mCT) XN and HOP led to a thickening of trabeculae in femurs and vertebral bodies. HOP increased serum osteocalcin (OC) (222.86 ± 39.62 pg/mL vs. 175.87 ± 58.91 pg/mL) and decreased tartrate-resistant acid phosphatase (TRACP) (0.714 ± 0.132 U/L vs. 1.251 ± 0.304 U/L), whereas in XN only decreased TRACP (0.738 ± 0.178 U/L). Results of our study showed that HOP and XN ameliorate ovariectomy induced disturbances in tail skin temperature (TST). Additionally, HOP exerts a mild protective effect on bone loss induced by decline in oestrogen level.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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