Changes In the lipid composition of rat hepatic microsomes induced by the diet

Abstract

The effect on the hepatic microsomes from rats fed with either virgin olive oil (10%) or fish oil (10%), with or without added cholesterol (1%), has been studied. The fatty acid composition, desaturase activities and microviscosity (membrane fluidity) using male Wistar rats after weaning were determined. The results show that the fatty acid composition and other properties of the hepatic microsomes change with the diet. After cholesterol feeding, an increase in membrane microviscosity and a decrease in the activity of Δ6 desaturase were observed.

Keywords

• fatty acid (composition in)
• liver
• microsomes
• rat