Ferulic acid alleviates the symptoms of diabetes in obese rats

Yuan Song; Taigang Wu; Qinhe Yang; Xiaoyin Chen; Mingfu Wang; Yong Wang; Xichun Peng; Shiyi Ou

Journal of Functional Foods (Jul 2014)

Ferulic acid alleviates the symptoms of diabetes in obese rats

Yuan Song,
Taigang Wu,
Qinhe Yang,
Xiaoyin Chen,
Mingfu Wang,
Yong Wang,
Xichun Peng,
Shiyi Ou

Affiliations

Yuan Song: Out-patient Department of University, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China
Taigang Wu: Department of Food Science and Engineering, Jinan University, Guangzhou 510632, Guangdong, China
Qinhe Yang: School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China
Xiaoyin Chen: School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China
Mingfu Wang: School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong
Yong Wang: Department of Food Science and Engineering, Jinan University, Guangzhou 510632, Guangdong, China
Xichun Peng: Department of Food Science and Engineering, Jinan University, Guangzhou 510632, Guangdong, China; Corresponding author. Tel.: +86 15899975229; fax: +86 20 85226630.
Shiyi Ou: Department of Food Science and Engineering, Jinan University, Guangzhou 510632, Guangdong, China; Corresponding author. Tel.: +86 13640210646; fax: +86 20 85226630.

Journal volume & issue: Vol. 9
pp. 141 – 147

Abstract

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The effect of ferulic acid on biochemical and histological properties, mRNA expression of HO-1 and GST in the liver and heart were investigated in obese, diabetes rats after ferulic acid administration for 16 weeks. The results showed that ferulic acid (60 mg/kg) decreased the activities of ALT, AST, CK, and LDH in the serum, by 53.5, 33.6, 47.8, and 405.5% respectively; and reduced cell apoptosis from 16.55 to 9.11% in the liver, and 11.27 to 5.09% in the heart. Ferulic acid significantly increased the antioxidant activity in the plasma, liver, and heart, and upregulated the mRNA expression of HO-1 and GST in the cells of liver and heart of the diabetes animals. Moreover, ferulic acid maintained the body weight, significantly decreased serum glucose and lipid, and advanced glycation end products in the plasma, liver, and heart. It can be concluded that ferulic acid can alleviate late-stage diabetes in obese rats.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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