Hepatoprotective effect of chlorogenic acid against chronic liver injury in inflammatory rats

Zhenlong Chen; Yuhui Yang; Shumei Mi; Qingsheng Fan; Xiaoming Sun; Baichuan Deng; Guoyao Wu; Yafei Li; Quancheng Zhou; Zheng Ruan

Journal of Functional Foods (Nov 2019)

Hepatoprotective effect of chlorogenic acid against chronic liver injury in inflammatory rats

Zhenlong Chen,
Yuhui Yang,
Shumei Mi,
Qingsheng Fan,
Xiaoming Sun,
Baichuan Deng,
Guoyao Wu,
Yafei Li,
Quancheng Zhou,
Zheng Ruan

Affiliations

Zhenlong Chen: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330006, China
Yuhui Yang: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330006, China; College of Food Science and Technology, Henan University of Technology, Zhengzhou, Henan 450001, China
Shumei Mi: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330006, China
Qingsheng Fan: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330006, China
Xiaoming Sun: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330006, China
Baichuan Deng: College of Animal Science, South China Agricultural University, Guangzhou, China
Guoyao Wu: Department of Animal Science, Texas A&M University, College Station, TX 77843, USA
Yafei Li: University Campus Hospital and Jiangxi Academy of Medical Science, Nanchang University, Nanchang, China; Corresponding authors.
Quancheng Zhou: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330006, China; School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo 255049, China
Zheng Ruan: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330006, China; Corresponding authors.

Journal volume & issue: Vol. 62

Abstract

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Chlorogenic acid (CGA) is a type of phenolic acid that has antioxidant and anti-inflammatory activities. In this study, we investigated the hepatoprotective effect of CGA in lipopolysaccharide (LPS)-treated rats. Supplementation with CGA attenuated (P < 0.05) hepatocyte necrosis and inflammatory cell infiltration, decreased (P < 0.05) the activities of serum transaminases and alkaline phosphatase and the level of total bilirubin, and increased (P < 0.05) the level of serum total protein in comparison with the LPS-only group. In addition, CGA potently inhibited (P < 0.05) the LPS-induced drop in the activities of mitochondrial NADH dehydrogenase and ATP synthase and the contents of ATP and AMP in the liver. Furthermore, CGA could partially counteract the changes induced by lipopolysaccharide in many metabolic pathways, such as energy metabolism, amino acid metabolism, and glutathione metabolism. In summary, our study showed that CGA supplementation had a protective effect against LPS-induced chronic liver injury.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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