Nutritional composition, toxicity, and the effects of Parkia biglobosa on the metabolic, somatic and oxidative parameters related to liver and kidney function of obese rats

Mirela Gouveia-Nhanca; Maria Luiza Rolim Bezerra; Yuri Mangueira do Nascimento; Evandro Ferreira da Silva; Josean Fechine Tavares; Gonçalo Mendes da Conceição; Rubens Teixeira de Queiroz; Luis António Tavares; Adriano Francisco Alves; Jailane de Souza Aquino

Journal of Functional Foods (Jan 2025)

Nutritional composition, toxicity, and the effects of Parkia biglobosa on the metabolic, somatic and oxidative parameters related to liver and kidney function of obese rats

Mirela Gouveia-Nhanca,
Maria Luiza Rolim Bezerra,
Yuri Mangueira do Nascimento,
Evandro Ferreira da Silva,
Josean Fechine Tavares,
Gonçalo Mendes da Conceição,
Rubens Teixeira de Queiroz,
Luis António Tavares,
Adriano Francisco Alves,
Jailane de Souza Aquino

Affiliations

Mirela Gouveia-Nhanca: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil
Maria Luiza Rolim Bezerra: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil
Yuri Mangueira do Nascimento: Pharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil
Evandro Ferreira da Silva: Pharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil
Josean Fechine Tavares: Pharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil
Gonçalo Mendes da Conceição: Centre for Higher Studies of Caxias, State University of Maranhão, Praça Duque de Caxias, s/n-Morro do Alecrim, Caxias, Maranhão, Brazil
Rubens Teixeira de Queiroz: Department of Systematics and Ecology, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil
Luis António Tavares: Ministry of Agriculture and Rural Development of Guinea-Bissau, Government Palace, Avenida dos Combatentes da Liberdade da Pátria, s/n, Bissau, Guinea-Bissau
Adriano Francisco Alves: Laboratory of General Pathology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil
Jailane de Souza Aquino: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil; Post Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), Cidade Universitária, s/n-Castelo Branco III, João Pessoa, Paraíba, Brazil; Corresponding author at: Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba (UFPB), CEP 58051-900 João Pessoa, Paraíba, Brazil.

Journal volume & issue: Vol. 124
p. 106479

Abstract

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Background: The pathophysiology of obesity is associated with somatic, metabolic and oxidative changes which can also compromise renal and hepatic function. Treatment of this condition involves dietary intervention, including incorporating foods rich in bioactive compounds such as Parkia biglobosa. This legume is rich in fibres and phenolic compounds such as 3,4-dihydroxybenzoic acid, catechin, and myricetin that can play a significant role in the adjuvant treatment of obesity. Thus, we evaluated the nutritional composition, toxicity, and the effects of Parkia biglobosa on metabolic, somatic and oxidative parameters, as well as the liver and kidney function of obese rats. Methods: Parkia biglobosa pulp was initially characterised and evaluated for its toxicity. Then, male Wistar rats were randomised into groups: healthy (HG); obese (OG); healthy (HPB) and obese (OPB) both treated with Parkia biglobosa (400 mg/kg). Somatic and biochemical parameters; triglyceride, cholesterol and total fat in faeces and liver; oxidative and histological parameters in the liver and kidney were all analysed. Results: Parkia biglobosa intake reduced the adiposity index; improved glucose tolerance, insulin resistance, leptinemia and lipid metabolism parameters, which impacted the minimization of hepatic steatosis and improved oxidative parameters in the kidney and liver in obese rats (OPB). These findings are related to the nutritional composition of this legume, such as the relationship between insoluble and soluble fibres, as well as the phenolic and mineral profile. Conclusion: The set of results showed that Parkia biglobosa had an anti-adiposity effect, improved biochemical including hormonal parameters and reversed the changes in hepatic and renal markers in obesity-induced rats.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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