Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development

Gabriele Carullo; Miriam Durante; Fabio Sciubba; Donatella Restuccia; Umile Gianfranco Spizzirri; Amer Ahmed; Maria Enrica Di Cocco; Simona Saponara; Francesca Aiello; Fabio Fusi

Journal of Functional Foods (Jun 2019)

Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development

Gabriele Carullo,
Miriam Durante,
Fabio Sciubba,
Donatella Restuccia,
Umile Gianfranco Spizzirri,
Amer Ahmed,
Maria Enrica Di Cocco,
Simona Saponara,
Francesca Aiello,
Fabio Fusi

Affiliations

Gabriele Carullo: Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence (2018–2022), University of Calabria, Ed. Polifunzionale, 87036 Arcavacata di Rende (CS), Italy
Miriam Durante: Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
Fabio Sciubba: Department of Chemistry, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, Italy
Donatella Restuccia: Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence (2018–2022), University of Calabria, Ed. Polifunzionale, 87036 Arcavacata di Rende (CS), Italy
Umile Gianfranco Spizzirri: Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence (2018–2022), University of Calabria, Ed. Polifunzionale, 87036 Arcavacata di Rende (CS), Italy
Amer Ahmed: Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
Maria Enrica Di Cocco: Department of Chemistry, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, Italy
Simona Saponara: Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy; Corresponding authors.
Francesca Aiello: Department of Pharmacy, Health and Nutritional Sciences, Department of Excellence (2018–2022), University of Calabria, Ed. Polifunzionale, 87036 Arcavacata di Rende (CS), Italy; Corresponding authors.
Fabio Fusi: Department of Biotechnologies, Chemistry & Pharmacy, Department of Excellence (2018–2022), University of Siena, Via Aldo Moro 2, 53100 Siena, Italy

Journal volume & issue: Vol. 57
pp. 328 – 334

Abstract

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The valorisation of agrochemical wastes has become a low cost and sustainable tendency for the development of functional food. In particular, these enriched products seem to be enjoyable tools to treat metabolic disorders. In this field, Calabrian autochthonous white grape pomaces (Mantonico and Pecorello cultivar) were firstly investigated for their vasoactive properties. Skins and seeds were extracted and characterized by NMR spectroscopy, revealig the presence of numerous vasoactive compounds. The effects of extracts were analyzed in in vitro experiments on rat aorta rings (with and without endothelium), contracted by phenylephrine or KCl. Seeds extracts showed, differently from skins, an appreciable endothelium-dependent, eNOS-mediated vasodilation in the range 1–100 µg/mL. From a food market point of view, all the extracts were enclosed into a pectin polymer matrix. In the same experimental conditions, the polymers demonstrated the persistance of vasodilator activity only for Pecorello seed extract, which presented the most rich chemical profile.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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