Journal of Functional Foods (Aug 2024)
Colostrum supplementation enhance mental health status and alleviate pain in patients with acetabular fracture: A randomized, controlled, clinical trial
Abstract
Introduction: Role of oral colostrum on mental health status, pain, and inflammatory markers in patients with acetabular fracture was investigated. Materials and Methods: For 21 days, the intervention group received 40 g of colostrum daily and the control group received a placebo. Changes in mental health status, pain, and serum levels of CRP and IL-6 were evaluated over 90 days. Results: The risk of depressive symptoms and sleep disturbances in the colostrum group (n = 41) was significantly lower than the control group (n = 39), 14 and 60 days after surgery. The risk of anxiety symptoms in the colostrum group, 2 and 3 months after surgery, was significantly lower than the control group.Generalized estimating equation showed that the mean pain score and serum levels of CRP and IL-6 in the colostrum group were significantly lower than the control group during 90 days of follow-up. Conclusion: Colostrum improves mental health status, pain, and inflammatory markers.Iranian Registry of Clinical Trials: IRCT20220424054643N1.