Novel antioxidant peptides from Yak bones collagen enhanced the capacities of antiaging and antioxidant in Caenorhabditis elegans

Yali Wang; Yidan Sun; Xingguo Wang; Yue Wang; Langxing Liao; Yonghui Zhang; Baishan Fang; Yousi Fu

Journal of Functional Foods (Feb 2022)

Novel antioxidant peptides from Yak bones collagen enhanced the capacities of antiaging and antioxidant in Caenorhabditis elegans

Yali Wang,
Yidan Sun,
Xingguo Wang,
Yue Wang,
Langxing Liao,
Yonghui Zhang,
Baishan Fang,
Yousi Fu

Affiliations

Yali Wang: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China
Yidan Sun: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China
Xingguo Wang: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China
Yue Wang: Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian, PR China
Langxing Liao: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China
Yonghui Zhang: College of Food and Biological Engineering, Jimei University, Xiamen, Fujian, PR China
Baishan Fang: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China; The Key Lab for Synthetic Biotechnology of Xiamen City, Xiamen University, Xiamen, Fujian, PR China; Corresponding authors at: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China (B. Fang and Y. Fu).
Yousi Fu: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China; Corresponding authors at: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, PR China (B. Fang and Y. Fu).

Journal volume & issue: Vol. 89
p. 104933

Abstract

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Two novel collagen peptides derived from Yak bones, UU1 (GASGPMGPR) and K7 (GLPGPM) were demonstrated to be antioxidative in vitro and in Caenorhabditis elegans. In vitro, UU1 and K7 shown decent scavenging activities on free radicals of DPPH, ABTS, ·OH and ·O–2. Their effects on worms, including the lifespans, locomotory behavior, and reproduction were further evaluated. Whether under normal or thermal conditions, UU1 and K7 extended the survival time accordingly, and promoted the reproduction. Additionally, UU1 and K7 remarkably attenuated the accumulations of reactive oxygen species (ROS) and malondialdehyde (MDA) and enhanced the activities of superoxide dismutase (SOD) and catalase (CAT) in worms. Furthermore, both UU1 and K7 impressively upregulated the expressions of daf-16, sod-3 and skn-1, but their effects on the hsf-1 and the sir-2.1 were distinct. Thus, UU1 and K7 two highly active antioxidant peptides were revealed and could be applied in antioxidant productions.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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