Inhibitory effects of saeu‐jeot extract on NLRP3 inflammasome activation and radiation‐induced micronucleus formation

Abstract

Abstract Purpose Saeu‐jeot, or shrimp paste, is a traditional Korean high‐salt fermented seafood. This study elucidated the effects of saeu‐jeot extract (SJE) on NLRP3 inflammasome activation and radiation‐induced micronucleus formation. Method We treated lipopolysaccharide‐primed mouse bone marrow‐derived macrophages with the NLRP3 inflammasome activators ATP and nigericin. We also analyzed the acute effects of ionizing radiation on micronucleated polychromatic erythrocytes (MnPCEs) in whole‐body gamma‐irradiated male BALB/c and C57BL/6 mice after oral administration of SJE. Results SJE significantly inhibited NLRP3 inflammasome activation, reducing IL‐1β secretion in vitro. In addition, the frequency of MnPCEs was significantly lower in SJE‐treated mice. Conclusions SJE has anti‐inflammatory effects and reduces radiation‐induced chromosome damage. Advance in knowledge: There are no reports concerning the effects of SJE on NLRP3 inflammasome activation or radioprotection. This experiment showed the radioprotective effects of saeu‐jeot.

Keywords

• inflammasome
• micronuclei
• NLRP3
• radiation
• saeu‐jeot