A Proposed New Path for Management of Health in Inherited Metabolic Disorders Using Engineered Probiotic Bacteria

Abstract

Caroline B Kurtz,1 Mona S Calvo2 1Synlogic Inc., Cambridge, MA, USA; 2Icahn School of Medicine at Mount Sinai, Manhattan, NY, USACorrespondence: Caroline B Kurtz, Email [email protected]: Dietary supplements represent a growing segment of the healthcare industry as consumers seek alternative methods to manage health concerns. Probiotics are dietary supplements that are broadly used to aid digestion and immune and metabolic health. Patients with disorders restricting the intake of particular nutrients must balance adequate nutrition with limitations in the intake of natural food ingredients. Synthetic biology has emerged in the last decade, allowing scientists to specifically engineer probiotic bacteria to perform functions in the GI tract, such as the elimination or reduction of specific nutrients from ingested food sources. Engineered probiotic bacteria have the potential to provide health benefits and improve the quality of life of patients with genetic or acquired metabolic disorders. One way to make them available to consumers is to develop specialized products as dietary supplements. Developers of such innovative products must follow new FDA guidance and work closely with FDA in consideration of the design, development, manufacturing, and labeling of engineered probiotics as dietary supplements.Keywords: probiotic dietary supplement, FDA, new dietary ingredient

Keywords

• probiotic dietary supplement
• fda
• new dietary ingredient