Pungent agents derived from the fruits of Zanthoxylum armatum DC. are beneficial for ameliorating type 2 diabetes mellitus via regulation of AMPK/PI3K/Akt signaling

Die Qian; Jun Chen; Yunying Xu; Chengxun He; Yamei Wu; Wei Peng; Xueping Li

Journal of Functional Foods (May 2024)

Pungent agents derived from the fruits of Zanthoxylum armatum DC. are beneficial for ameliorating type 2 diabetes mellitus via regulation of AMPK/PI3K/Akt signaling

Die Qian,
Jun Chen,
Yunying Xu,
Chengxun He,
Yamei Wu,
Wei Peng,
Xueping Li

Affiliations

Die Qian: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Jun Chen: Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
Yunying Xu: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Chengxun He: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Yamei Wu: Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China
Wei Peng: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Corresponding authors at: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Xueping Li: Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; Corresponding authors at: State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Journal volume & issue: Vol. 116
p. 106160

Abstract

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Type 2 diabetes mellitus (T2DM), the main type of diabetes, is a common chronic metabolic disease and a serious health concern worldwide. The aim of this study was to investigate the anti-diabetic effects and underlying mechanisms of pungent substances in Zanthoxylum armatum DC (ZA) fruit (PAZ), which are both edible and medicinal. We firstly investigated the possible molecular mechanisms of the PAZ on T2DM using network pharmacology and online databases. Furthermore, the predicted results were explored by Glucosamine induced AML12 experiments in vitro. After PAZ intervention, ROS levels decreased, MDA levels of oxidative stress indicators decreased, and SOD, GSH, and CAT levels increased compared to the model group. Thus, the pungent agents from the fruits of Z. armatum are beneficial for ameliorating type 2 diabetes mellitus via regulation of AMPK/PI3K/AKT signaling and reducing oxidative stress levels and exerting an anti-insulin resistance effect.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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