Hypoglycemic effect of inulin combined with ganoderma lucidum polysaccharides in T2DM rats

Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang

Journal of Functional Foods (Apr 2019)

Hypoglycemic effect of inulin combined with ganoderma lucidum polysaccharides in T2DM rats

Yaping Liu,
Yumeng Li,
Wenlingzi Zhang,
Mingzhe Sun,
Zesheng Zhang

Affiliations

Yaping Liu: State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
Yumeng Li: State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
Wenlingzi Zhang: State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
Mingzhe Sun: State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
Zesheng Zhang: State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China; Tianjin Food Safety & Low Carbon Manufacturing Collaborative Innovation Center, 300457 Tianjin, China; Corresponding author at: State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.

Journal volume & issue: Vol. 55
pp. 381 – 390

Abstract

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It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and ganoderma lucidum polysaccharides were administered orally to the T2DM rats for 5 weeks. Subsequently, the glycometabolism relevant parameters were evaluated in all rats, and the molecular mechanism including the key mRNA levels and protein expressions in PI3K/Akt pathway was explored. The results showed that the combination of inulin and ganoderma lucidum polysaccharides could significantly improve the glucose and lipid metabolism related parameters in T2DM rats, which seemed to be related to enhancing the insulin sensitivity, increasing the glycogen synthesis and facilitating the glucose transportation by regulating the PI3K/Akt pathway.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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