Effects of mulberry leaf and white kidney bean extract mix on postprandial glycaemic control in pre-diabetic subjects aged 45–65 years: a randomized controlled trial

Abstract

Mulberry leaves and white kidney beans may improve postprandial glycaemic control. However, data are lacking on the combined anti-diabetic effect of these two plant extracts among pre-diabetic individuals. This randomized controlled study aimed to evaluate the acute and chronic effects of mulberry leaf and white kidney bean extract mix (MWEM) on postprandial glycaemic control in 66 pre-diabetic subjects. In the acute effect test, ingestion of MWEM led to a significant decrease in the postprandial glucose, insulin, and C-peptide, as well as the incremental area under the curves from 0 to 120 min (iAUCs0–120min) for glucose, insulin, and C-peptide. In the chronic effect test, no significant treatment × time interactions were observed in the iAUCs0–120min, as well as the homeostatic model assessment-insulin resistance (HOMA-IR), haemoglobin A1c (HbA1c), and glycated serum protein (GSP) levels. The consumption of MWEM with a meal could potentially help to improve postprandial glycaemic control in pre-diabetic individuals.

Keywords

• Mulberry leaves
• 1-Deoxynojirimycin
• White kidney beans
• α-Amylase inhibitor
• Postprandial glycaemic control
• Pre-diabetes