Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells

Abstract

Deer antler extract contains chemical compounds and peptides which have been shown to exert many pharmacological functions. However, the extract may also exhibits potential particle characteristics at nanoscale thereby acting as intrinsic nanozyme upon processing. We aim to test the nanoscale effect on cancer cells. We found that the water extract contains nanoscale particles characterized by SEM, TEM, AFM, zeta potential, and exhibits nanozyme or co-nanozyme activities of phosphatase, catalase which has crosstalk associated with anti-prostate cancer cells viability, especially with combined inhibitor of MET kinase by co-targeting phosphorylation. Network pharmacology analysis also showed immune mechanisms. Docking analysis shows the potent antler extract compound mediated inhibition of MET kinase. Nanoscale particles and compounds from antler extract at least in part, contribute to anticancer mechanisms which would be a promising combination agent in anti-cancer via nanotechnology.

Keywords

• Nanoparticles
• Nanozyme
• Co-nanozyme
• Antler extract