Total saponins from Panax japonicus promote lipolysis of aging fat through the tyrosine hydroxylase signaling pathway

Mengzhen Xue; Wei Wu; Gang Zhou; Jihong Zhang; Shuwen Wang; Yaqi Hu; Yifan Zhang; Rui Wang; Qi Yuan; Yiyang Luo; Ding Yuan; Yumin He; Chengfu Yuan

Journal of Functional Foods (May 2024)

Total saponins from Panax japonicus promote lipolysis of aging fat through the tyrosine hydroxylase signaling pathway

Mengzhen Xue,
Wei Wu,
Gang Zhou,
Jihong Zhang,
Shuwen Wang,
Yaqi Hu,
Yifan Zhang,
Rui Wang,
Qi Yuan,
Yiyang Luo,
Ding Yuan,
Yumin He,
Chengfu Yuan

Affiliations

Mengzhen Xue: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Wei Wu: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Medicine and Health Science, China Three Gorges University, Yichang 443002, China
Gang Zhou: College of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; Yichang Hospital of Traditional Chinese Medicine, Yichang 443002, China
Jihong Zhang: Hubei Clinical Research Center for Functional Digestive Diseases of Traditional Chinese Medicine & Traditional Chinese Medicine Hospital of China Three Gorges University, Yichang 443002, China
Shuwen Wang: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Yaqi Hu: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Yifan Zhang: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Rui Wang: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
Qi Yuan: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Medicine and Health Science, China Three Gorges University, Yichang 443002, China
Yiyang Luo: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Medicine and Health Science, China Three Gorges University, Yichang 443002, China
Ding Yuan: College of Medicine and Health Science, China Three Gorges University, Yichang 443002, China
Yumin He: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Medicine and Health Science, China Three Gorges University, Yichang 443002, China
Chengfu Yuan: Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China; College of Basic Medical Science, China Three Gorges University, Yichang 443002, China; Corresponding author at: Department of Biochemistry, College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.

Journal volume & issue: Vol. 116
p. 106159

Abstract

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Aging and obesity are closely related. A key change in the adipose tissue during the aging process is the decline of lipolysis. The excitation of the sympathetic nerve system is a key pathway to promote lipolysis, but the underlying mechanism remains unclear. In this work, in vitro and in vivo aging models with and without tyrosine hydroxylase (TH) knockdown were treated with total saponins from Panax japonicus (TSPJs), and the expression of lipolysis-related proteins was examined. It was found that TSPJs could promote the expression of lipolysis-related genes and TH in adipocytes both in vitro and in vivo, and the expression of lipolysis-related genes was downregulated after TH knockdown. It was inferred that TSPJs could promote the excitation of sympathetic nerves by increasing the expression of TH in adipose tissue, which positively regulated the expression of lipases to revitalize lipolysis. The results suggested that TSPJs resisted aging-induced obesity and could be a potential medication for weight management.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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