Live and heat-killed cells of Lactobacillus plantarum Zhang-LL ease symptoms of chronic ulcerative colitis induced by dextran sulfate sodium in rats

Junhua Jin; Siqi Wu; Yuanhong Xie; Hui Liu; Xiuzhi Gao; Hongxing Zhang

Journal of Functional Foods (Aug 2020)

Live and heat-killed cells of Lactobacillus plantarum Zhang-LL ease symptoms of chronic ulcerative colitis induced by dextran sulfate sodium in rats

Junhua Jin,
Siqi Wu,
Yuanhong Xie,
Hui Liu,
Xiuzhi Gao,
Hongxing Zhang

Affiliations

Junhua Jin: Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Detection and Control of Spoilage Organisms and Pesticide Residues in Agricultural Products, Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China; Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China
Siqi Wu: Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Detection and Control of Spoilage Organisms and Pesticide Residues in Agricultural Products, Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China
Yuanhong Xie: Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Detection and Control of Spoilage Organisms and Pesticide Residues in Agricultural Products, Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China; Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China
Hui Liu: Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Detection and Control of Spoilage Organisms and Pesticide Residues in Agricultural Products, Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China
Xiuzhi Gao: Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Detection and Control of Spoilage Organisms and Pesticide Residues in Agricultural Products, Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China
Hongxing Zhang: Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Detection and Control of Spoilage Organisms and Pesticide Residues in Agricultural Products, Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China; Innovation Centre of Food Nutrition and Human Health (Beijing), Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China; Corresponding author at: Beijing University of Agriculture, No. 7 Beinong Road, Changping District, Beijing 102206, China.

Journal volume & issue: Vol. 71
p. 103994

Abstract

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Controversial results were yielded in some studies on the effects of Lactobacillus on ulcerative colitis (UC). In this work, we evaluated the effect of live or heat-killed Lactobacillus plantarum Zhang-LL cells and cell supernatants on dextran sulfate sodium (DSS)-induced UC in rats. The tested subjects were gavaged to rats for 7 days, and then 5% was used DSS repeatedly to induce chronic UC. The results of a 42-day experiment, indicated consistently and significantly that Both living and heat-killed cells of L. plantarum Zhang-LL could down-regulate content of pro-inflammatory cytokines (TNF-α, INF-γ) in serum, reduce intestinal permeability by increasing the expression of tight junction proteins zo-1, claudin-1 and occludin in colon tissue, and maintain intestinal microbiota stability by increasing intestinal microbiota diversity to alleviate the symptoms of chronic UC in rats with 100% survival rate. Of concern is, the heat-killed cells of L. plantarum Zhang-LL were more effective against DSS-induced chronic UC in rats.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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