Apple extract protects against indomethacin-induced gastric ulcers in rats by suppressing oxidative stress – The implication of Nrf-2/HO-1 signaling pathway: In silico and in vivo studies

Enas Reda Abdelaleem; Miada F. Abdelwahab; Nada Mohamed Abdel-Wahab; Dalia H. Abu-Baih; Azza M. Abdel Zaher; Faisal H. Altemani; Naseh A. Algehainy; Usama Ramadan Abdelmohsen; Hussain T. Bakhsh; Fatma Alzahraa Mokhtar; Alshymaa Abdel-Rahman Gomaa

Journal of Functional Foods (Jan 2024)

Apple extract protects against indomethacin-induced gastric ulcers in rats by suppressing oxidative stress – The implication of Nrf-2/HO-1 signaling pathway: In silico and in vivo studies

Enas Reda Abdelaleem,
Miada F. Abdelwahab,
Nada Mohamed Abdel-Wahab,
Dalia H. Abu-Baih,
Azza M. Abdel Zaher,
Faisal H. Altemani,
Naseh A. Algehainy,
Usama Ramadan Abdelmohsen,
Hussain T. Bakhsh,
Fatma Alzahraa Mokhtar,
Alshymaa Abdel-Rahman Gomaa

Affiliations

Enas Reda Abdelaleem: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Miada F. Abdelwahab: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Nada Mohamed Abdel-Wahab: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Dalia H. Abu-Baih: Department of Biochemistry & Molecular Biology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt
Azza M. Abdel Zaher: Department of Pathology, Faculty of Medicine, Minia University Minia 61519, Egypt
Faisal H. Altemani: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia
Naseh A. Algehainy: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia
Usama Ramadan Abdelmohsen: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt; Corresponding author at: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Hussain T. Bakhsh: Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Fatma Alzahraa Mokhtar: Department of Pharmacognosy, Faculty of Pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida 44813, Sharkia, Egypt
Alshymaa Abdel-Rahman Gomaa: Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Journal volume & issue: Vol. 112
p. 105926

Abstract

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Gastric ulcers represent a worldwide health problem, characterized by erosions with different degrees in the gastrointestinal mucosa. In the current study, we explore the protective effects of the extract of apple seeds (Malus domestica, family: Rosaceae), regarded as environmental wastes, against indomethacin-induced gastric ulcers in rats. The chemical composition of the seeds extract was investigated through liquid chromatography high-resolution electrospray ionization mass spectrometry (LC-HR-ESI-MS). The metabolomics profiling resulted in identification of 17 compounds (1–17) of different chemical classes. The gene ontology analysis demonstrated that the total extract of M. domestica seeds possess an antiulcer activity through PI3K-Akt signaling pathway as the top identified signaling pathway. The present research work evidenced the reuse of apple seeds waste as an effective therapy to treat NSAIDs-induced gastric ulcer, attributed to its anti-inflammatory and antioxidant properties. It is important to note that the extract does not cause the undesirable effects of traditional antisecretory drugs.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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