npj Vaccines (Sep 2024)
Evaluation of effectiveness and safety of Subolesin anti-tick vaccine in Ugandan multi-site field trial
- Fredrick Kabi,
- Marinela Contreras,
- Jimmy Semakula,
- Marta Sánchez-Sánchez,
- Clara Muñoz-Hernández,
- Swidiq Mugerwa,
- Paul Kasaija,
- Halid Kirunda,
- Gabriela de la Fuente,
- Rubén Fernández-Melgar,
- Marta Rafael,
- Isabel G. Fernández de Mera,
- Moses Matovu,
- Ivan Kyakuwa,
- Moses Dhikusooka,
- Godfrey Nsereko,
- Paul Boma,
- James Bugeza,
- Mwesigwa Moses,
- Agnes Namukasa,
- Philip Obonyo,
- Nicholas Ssekabunga,
- Okeny E. Adyero,
- Justus Rutaisire,
- Christian Gortazar,
- José de la Fuente
Affiliations
- Fredrick Kabi
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Marinela Contreras
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- Jimmy Semakula
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Marta Sánchez-Sánchez
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- Clara Muñoz-Hernández
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- Swidiq Mugerwa
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Paul Kasaija
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Halid Kirunda
- Mbarara Zonal Agricultural Research and Development Institute (Mbarara ZARDI), National Agricultural Research Organization
- Gabriela de la Fuente
- Sabiotec, Edificio incubadora de empresas UCLM, Camino de Moledores s/n
- Rubén Fernández-Melgar
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- Marta Rafael
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- Isabel G. Fernández de Mera
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- Moses Matovu
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Ivan Kyakuwa
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Moses Dhikusooka
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Godfrey Nsereko
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Paul Boma
- Nabuin ZARDI, 9HQG+5R7 Lorengdwat road
- James Bugeza
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Mwesigwa Moses
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Agnes Namukasa
- Uganda government prison farm, GH2V+93H
- Philip Obonyo
- Uganda government prison farm, 3FJ7+PCH
- Nicholas Ssekabunga
- Mbarara Zonal Agricultural Research and Development Institute (Mbarara ZARDI), National Agricultural Research Organization
- Okeny E. Adyero
- Uganda government prison farm, GH2V+93H
- Justus Rutaisire
- National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization
- Christian Gortazar
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- José de la Fuente
- SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM)
- DOI
- https://doi.org/10.1038/s41541-024-00966-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Abstract Vaccines are the most effective and sustainable intervention to control ticks and tick-borne diseases (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a field trial evaluating tick vaccine efficacy, effectiveness, and safety in cattle infested with multiple tick species in different Ugandan agro-ecological zones. Vaccination with SUB was safe with a protective capacity against anemia and infection, and reduced the number of infested cattle, tick fitness (feeding and reproduction) with vaccine effectiveness against multiple tick species between 93.2% at 167-196 days post-vaccination (dpv) and 61.4% at 251–327 dpv. Total integrated vaccine efficacy/effectiveness was estimated as 98.8%. The Subolesin-based vaccine is protective against multiple cattle tick infestations under field conditions in Uganda. These results support registration and commercialization of the vaccine to reduce tick populations and associated risks for human and animal TBD and chemical acaracides in Uganda.
