Undaria pinnatifida Sporophyll and Gracilaria verrucosa Attenuate obesity-induced fat accumulation, adipose tissue macrophage infiltration, and systemic insulin resistance

Eunyoung Kim; Jiamei Cui; Kayeon Ko; Zemin Li; Yunpeng Wang; Soo Youn Choi; Yunkyoung Lee; Guiguo Zhang

Journal of Functional Foods (Nov 2024)

Undaria pinnatifida Sporophyll and Gracilaria verrucosa Attenuate obesity-induced fat accumulation, adipose tissue macrophage infiltration, and systemic insulin resistance

Eunyoung Kim,
Jiamei Cui,
Kayeon Ko,
Zemin Li,
Yunpeng Wang,
Soo Youn Choi,
Yunkyoung Lee,
Guiguo Zhang

Affiliations

Eunyoung Kim: Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Republic of Korea; China-South Korea International Joint Laboratory of Functional Polysaccharides in Shandong Province, Taian City 271018, China
Jiamei Cui: Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Republic of Korea; China-South Korea International Joint Laboratory of Functional Polysaccharides in Shandong Province, Taian City 271018, China
Kayeon Ko: Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Republic of Korea; China-South Korea International Joint Laboratory of Functional Polysaccharides in Shandong Province, Taian City 271018, China
Zemin Li: China-South Korea International Joint Laboratory of Functional Polysaccharides in Shandong Province, Taian City 271018, China; Department of Animal Nutrition, Shandong Agricultural University, Taian City 271018, China; Key Laboratory of Efficient Utilization of Non-grain Feed Resources, Taian City 271018, China
Yunpeng Wang: China-South Korea International Joint Laboratory of Functional Polysaccharides in Shandong Province, Taian City 271018, China; Department of Animal Nutrition, Shandong Agricultural University, Taian City 271018, China; Key Laboratory of Efficient Utilization of Non-grain Feed Resources, Taian City 271018, China
Soo Youn Choi: Department of Biology, Jeju National University, Jeju 63243, Republic of Korea
Yunkyoung Lee: Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Republic of Korea; China-South Korea International Joint Laboratory of Functional Polysaccharides in Shandong Province, Taian City 271018, China; Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea; Corresponding authors at: Jeju National University, Jeju 63243, Republic of Korea (Y. Lee); Shandong Agricultural University, Taian City 271018, China (G. Zhang).
Guiguo Zhang: China-South Korea International Joint Laboratory of Functional Polysaccharides in Shandong Province, Taian City 271018, China; Department of Animal Nutrition, Shandong Agricultural University, Taian City 271018, China; Key Laboratory of Efficient Utilization of Non-grain Feed Resources, Taian City 271018, China; Corresponding authors at: Jeju National University, Jeju 63243, Republic of Korea (Y. Lee); Shandong Agricultural University, Taian City 271018, China (G. Zhang).

Journal volume & issue: Vol. 122
p. 106509

Abstract

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The potential health-promoting effects of two edible seaweeds, Undaria pinnatifida sporophyll (UPS) and Gracilaria verrucosa (GV), were investigated by using in vitro and in vivo models. Water extracts of UPS and GV inhibited lipid accumulation in 3T3-L1 adipocytes by downregulating adipogenesis-related genes and stimulated lipolysis in mature adipocytes. In C57BL/6 mice, supplementation with UPS and GV powders ameliorated diet-induced obesity, insulin resistance, and systemic inflammation, resulting in lighter subcutaneous adipose tissue and decreased macrophage markers (F4/80, Cd11c, Cd206) and proinflammatory genes (Tnf-α, Il-1β, Il-6, Ccl2) in gonadal adipose tissue. Liver weight and hepatic triglyceride levels were also significantly lowered. Taken together, UPS and GV supplementation effectively prevented diet-induced obesity and chronic inflammation making them promising dietary ingredients for managing obesity and its associated disorders.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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