Metabolic effects of dietary supplementation of Lycium barbarum polysaccharides on serum and urine metabolomics in a young healthy male population

Hui Xia; Huali Tang; Feng Wang; Xian Yang; Zhaodan Wang; Hechun Liu; Da Pan; Shaokang Wang; Guiju Sun

Journal of Functional Foods (Jul 2018)

Metabolic effects of dietary supplementation of Lycium barbarum polysaccharides on serum and urine metabolomics in a young healthy male population

Hui Xia,
Huali Tang,
Feng Wang,
Xian Yang,
Zhaodan Wang,
Hechun Liu,
Da Pan,
Shaokang Wang,
Guiju Sun

Affiliations

Hui Xia: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Huali Tang: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Feng Wang: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Xian Yang: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Zhaodan Wang: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Hechun Liu: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Da Pan: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Shaokang Wang: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China
Guiju Sun: Corresponding author.; Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, PR China

Journal volume & issue: Vol. 46
pp. 440 – 448

Abstract

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Lycium barbarum polysaccharides (LBP) has been reported to possess abundant bioactive activities, such as anti-cancer, antioxidant activities, anti-diabetes, immune function and anti-fatigue, however, whether it can influence the healthy adults, especially at metabolomics level is still unclear. Therefore, metabolomics effects of LBP on adults were investigated in the present study. 42 males were randomly divided into LBP supplementation (300 mg/d) and control group for 4 weeks, followed by anthropometric, biochemical indexes, and metabolic profiles detection. LBP was determined with 3.74 kDa, consisted of fucose, rhamnose, amino-galactose, galactose, glucose, mannose and fructose with a molar ratio of 0.02:0.08:0.03:0.11:46.67:0.37:4.72. Dietary LBP supplementation decreased the TG/HDL index significantly. d-talose decreased, phosphate and leucine increased significantly in serum. 4-Hydroxymandelonitrile 1 increased, and tyrosine 1, 3-Aminoisobutyric acid 1, threitol and ribose decreased significantly in urine. Eight metabolites were simultaneously assessed by indicating the glycerophospholipid metabolism and tyrosine metabolism after LBP supplementation in males.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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