Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats

Abstract

The beneficial effect of a commercially available β-glucan-enriched extract (BGEE) from cereal grain, against a diabetes-induced hepatic redox imbalance and inflammatory response in streptozotocin-induced diabetic rats was evaluated. Diabetic rats that were treated with BGEE exhibited lower hyperglycaemia and improved biochemical parameters of liver damage. BGEE attenuated hepatic oxidative stress, revealed by a decreased concentration of thiobarbituric acid reactive substances and a restored GSH/GSSG ratio. BGEE also exerted an anti-inflammatory effect on the liver, evidenced by the normalization of the serum concentrations of the “positive” and “negative” acute-phase proteins, α2-macroglobulin and albumin, respectively, as well as by upregulation of anti-inflammatory cytokine IL-10 and IL-4 mRNA expression, and inhibition of RAGE/NF-κB signaling. These findings suggest that BGEE application exerts a beneficial effect in the liver of streptozotocin-induced diabetic rats via its antioxidant and anti-inflammatory activities, and that it therefore possesses an important potential in diabetes management.

Keywords

• Acute-phase proteins
• β-Glucan
• Diabetes
• Liver
• Oxidative stress
• Inflammation