Protective effects of the extract from longan flower against hepatic ischemia/reperfusion injury in rats

Cheng-Chu Hsieh; Shih-Min Hsu; Lucy Sun Hwang; Jen-Hwey Chiu; Wen-Chien Lu; Ying-Ling Wu; Shu-Chen Hsieh

Journal of Functional Foods (May 2015)

Protective effects of the extract from longan flower against hepatic ischemia/reperfusion injury in rats

Cheng-Chu Hsieh,
Shih-Min Hsu,
Lucy Sun Hwang,
Jen-Hwey Chiu,
Wen-Chien Lu,
Ying-Ling Wu,
Shu-Chen Hsieh

Affiliations

Cheng-Chu Hsieh: Department and Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan; Biologics Division, Animal Health Research Institute, Council of Agriculture, Executive Yuan, New Taipei City 251, Taiwan
Shih-Min Hsu: Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan
Lucy Sun Hwang: Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan
Jen-Hwey Chiu: Division of General Surgery, Department of Surgery, Veterans General Hospital, Taipei 112, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
Wen-Chien Lu: Department of Medicinal Botanical and Health Applications, Da-Yeh University, Changhua 515, Taiwan
Ying-Ling Wu: Department and Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan; Corresponding author. Department and Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan. Tel.: +886 2 3366 1302; fax: +886 2 2366 1475.
Shu-Chen Hsieh: Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan; Corresponding author. Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan. Tel.: +886 2 3366 9871; fax: +886-2-23620849.

Journal volume & issue: Vol. 15
pp. 570 – 579

Abstract

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Ischemia/reperfusion (I/R) injury has a complex pathophysiology resulting from a number of contributing factors. The effect of longan flower ethyl acetate extract (LFEE) on hepatic I/R injury in rats was examined. Aspartate aminotransferase, alanine aminotransferase, hepatic thiobarbituric acid reactive substances (TBARS), interleukin-1β, interleukin-6, interleukin-10, tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2 activities were significantly increased after I/R injury, but decreased in the groups with LFEE treatment. Significant decrease in hepatic glutathione levels after I/R injury was observed upon LFEE treatment. NADPH:quinone oxidoreductase 1 activity was significantly increased after I/R injury, and it was further increased in the groups with LFEE treatment. Histological results indicated that LFEE was effective in improving liver tissue morphology during I/R injury. Therefore, LFEE might offer a novel intervention for patients suffering from I/R of the liver especially in the process of hepatotomy and liver transplantation.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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