Water extract from Salvia plebeia ameliorates progression of non-alcoholic fatty liver disease via inhibition of oxidative stress inflammation reaction

Abstract

The lipid accumulation in the liver causes the inflammatory response by the production and secretion of proinflammatory cytokines and the generation of oxidative stress accumulated by the imbalance of the antioxidant system. The study was assessed in free fatty acid-induced HepG2 cells and diet-induced C57BL/6N mice by investigating mRNA and protein expression. S. plebeia inhibited lipid accumulation, oxidative stress, and controlled the inflammatory response. S. plebeia was shown to be effective in alleviating pathological damage caused by the expression of FXR/LXR/AMPK. When confirming the expression of antioxidant enzymes and Nrf2, it was confirmed that S. plebeia inhibited oxidative stress in the liver. In addition, it was revealed that hepatic inflammation could be regulated by reducing the activation of NF-κB and NF-κB-dependent cytokine production. Therefore, S. plebeia could be an effective therapeutic strategy in the development of NAFLD as well as steatosis.

Keywords

• Fatty liver
• Steatosis
• Oxidative stress
• Inflammation
• Fibrosis
• High-fat diet